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Therapeutic effects of a novel electrode for transcranial direct current stimulation in ischemic stroke mice

Writer 홍보실 / [홍보실] Date 2024-04-15 Hit 458

'Therapeutic effects of a novel electrode for transcranial direct current stimulation in ischemic stroke mice'

Non-invasive transcranial direct current stimulation (tDCS), a promising stimulation tool to modulate a wide range of brain disorders, has major limitations, such as poor cortical stimulation intensity and focality. We designed a novel electrode for tDCS by conjugating a needle to a conventional ring-based high-definition (HD) electrode to enhance cortical stimulation efficacy. HD-tDCS (43 µA/mm², charge density 51.6 kC/m², 20 min) was administered to male C57BL/6J mice subjected to early-stage ischemic stroke. The new HD-tDCS application, showing a higher electric potential and spatial focality based on computational modeling, demonstrated better therapeutic effects than conventional HD-tDCS in alleviating motor and cognitive deficits, with a decrease in infarct volume and inflammatory response. We assessed different electrode configurations in the new HD electrode; the configurations variously showed potent therapeutic effects, ameliorating neuronal death in the peri-infarct region via N-methyl-D-aspartate-dependent sterol regulatory element-binding protein 1 signaling and related inflammatory factors, further alleviating motor and cognitive deficits in stroke. This new HD-tDCS application showed better therapeutic effects than those with conventional HD-tDCS in early-stage stroke via the amelioration of neuronal death in the penumbra. 


* Reference

Authors (Department of Korean Medical Science, Pusan National University)

 · First author: Da Hee Jung 

 · Corresponding authors: Prof. Byung Tae Choi, Prof. Hwa Kyoung Shin

Title of original paperTherapeutic effects of a novel electrode for transcranial direct current stimulation in ischemic stroke mice

Journal: Theranostics

DOI: 10.7150/thno.90779.

https://www.thno.org/v14p1325.htm